Figure 5

Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone

De Souza W*, Barrias ES and Borges TR

Published: 17 October, 2018 | Volume 1 - Issue 1 | Pages: 014-023


Figure 5:

Transmission electron micrographs of intracellular amastigotes after 24 hours of treatment with posaconazole and amiodarone. (A) Untreated amastigotes inside peritoneal macrophages display a normal morphology. N, nucleus; k, kinetoplast; F, flagellum; G, Golgi). (B) After 24 hours of treatment with 1 nM posaconazole, amastigotes appear with autophagic structures (arrow) and dilated Golgi complex lamellae (asterisks). (C–D) Treatment of intracellular amastigotes with 0.5 µM amiodarone caused alterations in the kinetoplast (k), with membrane detachment (arrow) and appearance of internal vesicles (arrowhead).

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001003 Cite this Article Read Full Article PDF

More Images

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?