Figure 1

Trypanosoma dionisii as an experimental model to study anti-Trypanosoma cruzi drugs: A comparative analysis with benznidazole, posaconazole and amiodarone

De Souza W*, Barrias ES and Borges TR

Published: 17 October, 2018 | Volume 1 - Issue 1 | Pages: 014-023


Figure 1:

Trypanosoma cruzi and Trypanosoma dionisi epimastigotes incubated in the presence of benznidazole, posaconzole and amiodarone inhibit growth, but the inhibition occurs at lower concentrations in T. dionisii. A–F: Growth curve of epimastigote forms of T. cruzii and T. dionisii treated with 0.5, 1, 5, 10 and 20 µM of Bzn (A-B), 0.5, 1, 3, 5 and 10 µM of posaconazole (C-D) and 0.5, 1, 3, 5 and 10 µM of amiodarone (E-F). The drugs were added with 24 h of culture. The number of parasites was determined every day over three days using a Neubauer chamber and a light microscope (objective 40×, NA=0.9, phase contrast). The results are expressed as the mean of three independent experiments.

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001003 Cite this Article Read Full Article PDF

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