Figure 3

Coronavirus COVID-19 surface properties: Electrical charges status

Luisetto M*, Tarro G, Khaled Edbey, Farhan Ahmad Khan, Ahnaf Ilman, Yesvi AR, Nili BA, Fiazza C, Mashori GR, President, IMA Academy and Italy

Published: 13 April, 2021 | Volume 4 - Issue 1 | Pages: 016-027


Figure 3:

Structural- Chemistry and Identifying Surface-Active Species of the Virus(A) A central- slice through a cryo-EM tomogram of mouse hepatitis -virus for showing the existence of S on the outer surface of virions. (B) Structure of the SARS-CoV-2 spike- glycoprotein with highlighting corresponding functional- groups (protein- database [PDB]: 6VXX). Grey, blue, and red spheres are carbon, nitrogen, and oxygen atoms, respectively. The molecular- structure is colored based on hydrophobicity; colored from red (hydrophilic) to green (hydrophobic). It utilizes the experimentally attained hydrophobicity scale that relied on whole-residue free energies of transfer DG (kcal/mol) from water to 1-Palmitoyl-2-oleoyl-phosphatidyl-choline (POPC) interface. (C) Model representation of SARS-CoV-2 with respective proteins assembly. Key molecular- interactions among proteins on the surface of the virus -particle are shown as gray dash lines, ‘‘hydrophobic interactions,’’ and blue dash lines, ‘‘hydrogen bonding (–OH-----O),’’ (PDB: 6VYB). Some key surface-active moieties of SARS-CoV-2 are denoted as hydroxyl, amine, carbonyl, and carboxylic- acid functional groups FROM :Surface Chemistry Can Unlock Drivers of Surface Stability of SARS-CoV-2 in a Variety of Environmental Conditions.

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001021 Cite this Article Read Full Article PDF

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