Abstract

Case Report

The Urinary Microbiome: Shifting Paradigms from Sterile Urine to Microbial Dysbiosis in Chronic Pelvic Pain Syndrome

Mohammed Amine Elafari*, Mohammed Amine Bibat, Mamad Ayoub, Amine Slaoui, Tarik Karmouni, Abdelatif Koutani and Khalid Elkhader

Published: 13 April, 2026 | Volume 9 - Issue 1 | Pages: 022-026

The prevailing dogma regarding urinary tract sterility has been fundamentally challenged by advances in culture-independent molecular techniques. The urinary microbiome, also known as the urobiome, is defined as a complex ecosystem comprising bacteria, fungi, and viruses. This microbiome plays a pivotal role in maintaining urological health. Emerging evidence suggests a potential link between urinary microbial dysbiosis and the pathogenesis of Urologic Chronic Pelvic Pain Syndrome (UCPPS), a clinical umbrella term that explicitly encompasses two major phenotypes: Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS).
This review examines the paradigm shift in understanding urinary tract microbiology, characterizes the urobiome in health and disease, and explores the therapeutic implications of microbiome-targeted interventions for UCPPS management.

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001036 Cite this Article Read Full Article PDF

Keywords:

Urinary microbiome; Urobiome; Chronic pelvic pain syndrome; IC/BPS; CP/CPPS; Dysbiosis; Metagenomics; Urological disorders

References

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