Abstract

Perspective

Hypochlorous acid has emerged as a potential alternative to conventional antibiotics due to its broad-spectrum antimicrobial activity

Maher M Akl*

Published: 30 March, 2023 | Volume 6 - Issue 1 | Pages: 001-004

Hypochlorous acid (HOCl) is a potent antimicrobial agent that has recently gained attention as a potential alternative to conventional antibiotics. HOCl is produced by the human immune system in response to infection and is known for its broad-spectrum antimicrobial activity. It is effective against a wide range of microorganisms, including bacteria, viruses, and fungi, and has been shown to be more effective than many conventional antibiotics. One of the key advantages of HOCl is its ability to kill bacteria without promoting the development of antibiotic resistance. Unlike conventional antibiotics, which target specific bacterial structures or processes, HOCl acts by disrupting multiple cellular components, making it much more difficult for bacteria to develop resistance. Another advantage of HOCl is its safety profile. Unlike many conventional antibiotics, HOCl is not toxic to human cells and does not cause side effects such as gastrointestinal upset or allergic reactions. Overall, HOCl shows great promise as a potential alternative to conventional antibiotics, particularly in the face of rising antibiotic resistance. With further research, it may become an important tool in the fight against infectious diseases. Herein, we discuss the mechanisms of HOCl antimicrobial action, its potential clinical applications, and future directions for research. This review aims to provide an overview of the use of hypochlorous acid (HOCl) as an antibiotic agent.

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001026 Cite this Article Read Full Article PDF

References

  1. Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, Gould IM. Antibiotic resistance—the need for global solutions.The Lancet infectious diseases. 2013; 13(12): 1057-1098.
  2. World Health Organization (2015) Global action plan on antimicrobial resistance. ISBN, 978-92.
  3. Centers for Disease Control and Prevention (2019) Antibiotic resistance threats in the United States, 2019. US Department of Health and Human Services, CDC.
  4. O’Neill J. Tackling drug-resistant infections globally: final report and recommendations. The review on antimicrobial resistance. 2016.
  5. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015 Apr;40(4):277-83. PMID: 25859123; PMCID: PMC4378521.
  6. Unangst PC. Hypochlorous Acid. In: Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons, Ltd; 2001.
  7. Galani IE, Andreakos E. Neutrophils in viral infections: Current concepts and caveats. J Leukoc Biol. 2015 Oct;98(4):557-64. doi: 10.1189/jlb.4VMR1114-555R. Epub 2015 Jul 9. PMID: 26160849.
  8. Akl MM, Nazmy EA, El-Khouly OA. Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice. Journal of Bioscience and Aplied Research. 2022; 8:212-220.
  9. Hakim H, Thammakarn C, Suguro A, Ishida Y, Kawamura A, Tamura M, Satoh K, Tsujimura M, Hasegawa T, Takehara K. Evaluation of sprayed hypochlorous acid solutions for their virucidal activity against avian influenza virus through in vitro experiments. J Vet Med Sci. 2015 Feb;77(2):211-5. doi: 10.1292/jvms.14-0413. Epub 2014 Nov 24. PMID: 25421399; PMCID: PMC4363024.
  10. Del Rosso JQ, Bhatia N. Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes. J Clin Aesthet Dermatol. 2018 Nov;11(11):36-39. Epub 2018 Nov 1. PMID: 30588272; PMCID: PMC6303114.
  11. Winterbourn CC, Kettle AJ. Redox reactions and microbial killing in the neutrophil phagosome. Antioxid Redox Signal. 2013 Feb 20;18(6):642-60. doi: 10.1089/ars.2012.4827. Epub 2012 Oct 9. PMID: 22881869.
  12. Pullar JM, Vissers MC, Winterbourn CC. Living with a killer: the effects of hypochlorous acid on mammalian cells. IUBMB Life. 2000 Oct-Nov;50(4-5):259-66. doi: 10.1080/713803731. PMID: 11327319.
  13. Spickett CM. The lipid peroxidation product 4-hydroxy-2-nonenal: advances in chemistry and analysis. Redox Biology. 2014; 2: 893-901.
  14. O'May C, Tufenkji N. The swarming motility of Pseudomonas aeruginosa is blocked by cranberry proanthocyanidins and other tannin-containing materials. Appl Environ Microbiol. 2011 May;77(9):3061-7. doi: 10.1128/AEM.02677-10. Epub 2011 Mar 4. PMID: 21378043; PMCID: PMC3126419.
  15. Li X, Fang Y, Li Q, Zhang J, Liu J. The use of hypochlorous acid as a disinfectant against Piscine orthoreovirus (PRV). Aquaculture. 2017; 473: 201-207.
  16. Chen H, Wang D, Xia Q, Qian Y, Shi X, Shen J. Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. Journal of burns and wounds. 2018; 17.
  17. Zhang Y, Zhu S, Lu X, Xu T, Zheng Y, Fan X. Hypochlorous acid-releasing injectable hydrogels with in situ-formed calcium phosphate for enhanced antibacterial effect and osteogenesis. ACS applied materials & interfaces. 2019; 11(27): 24123-24135.
  18. Hypochlorous acid generation at platinum and gold electrodes for water disinfection. Electrochemistry. 84(7): 458-460.
  19. Nakanishi Y, Iwata M, Uchida K. Hypochlorous acid generation at platinum and gold electrodes for water disinfection. Electrochemistry. 2016; 84(7): 458-460.
  20. Goudarzi M, Shirmohammadi A, Ebrahiminezhad A. Hypochlorous acid generation using a three-dimensional electrode reactor and its application in Escherichia coli inactivation. Journal of Environmental Chemical Engineering. 2019; 7(6): 103438.
  21. Cieplik F, Pummer A, Leibl C, Regensburger J, Tabenski L, Hiller KA, Buchalla W. Oxygen-dependent photosensitization by the chlorin e6 derivative DBC: intracellular accumulation and cell death mechanisms in Pseudomonas aeruginosa. Frontiers in microbiology. 2018; 9: 1608.
  22. Pattison DI, Davies MJ. Actions of HOCl and the Peroxidase-Halide System in the Oxidation of Low-Density Lipoprotein: Measurement of Chloramines and Chloramides. Journal of Biological Chemistry. 2001; 276(25):22456-22466. doi:10.1074/jbc.M100919200
  23. Malle E, Buch T, Grone HJ. Myeloperoxidase in kidney disease. Kidney Int. 2003 Dec;64(6):1956-67. doi: 10.1046/j.1523-1755.2003.00336.x. PMID: 14633118.
  24. Zhang P, Wang D, Zhao C. Hybroschurose acid, a novel LSD1 inhibitor, suppresses inflammatory responses in macrophages and collagen-induced arthritis in mice. Biochem Pharmacol. 2021; 194:114308. doi:10.1016/j.bcp.2021.114308.
  25. Yang X, Han H, Deeb D. Hybroschurose acid, a novel LSD1 inhibitor, inhibits the proliferation and induces the apoptosis of human breast cancer cells. Oncol Rep. 2019; 42(4):1364-1374. doi:10.3892/or.2019.7245.
  26. Application for Inclusion in the. 2021 WHO Essential Medicines List. Hypochlorous Acid (HOCl) for disinfection, antisepsis, and wound care.
  27. Yang Y, Yang Z, Wang F. Hypochlorous acid and chlorine dioxide effectively disinfect COVID-19 virus-contaminated materials. Journal of Hospital Infection. 2021; 108:85-94. doi:10.1016/j.jhin.2020.12.001.
  28. Kim S, Lim B, Park S. Antibacterial activity and cytotoxicity of a hypochlorous acid-based irrigant and sodium hypochlorite. Journal of Prosthetic Dentistry. 2019; 122(6):507-514. doi:10.1016/j.prosdent.2018.10.004.
  29. Zhang P, Wang D, Zhao C. Hybroschurose acid, a novel LSD1 inhibitor, suppresses inflammatory responses in macrophages and collagen-induced arthritis in mice. Biochem Pharmacol. 2021; 194:114308. doi:10.1016/j.bcp.2021.114308.
  30. Yang X, Han H, Deeb D, et al. Hybroschurose acid, a novel LSD1 inhibitor, inhibits the proliferation and induces the apoptosis of human breast cancer cells. Oncol Rep. 2019;42(4):1364-1374. doi:10.3892/or.2019.7245.
  31. Kim JH, Lee JO, Lee SK. Hybroschurose acid, a novel lysine-specific demethylase 1 inhibitor, suppresses neuroinflammation in vitro and in vivo. Biochem Pharmacol. 2020; 172:113772. doi:10.1016/j.bcp.2019.113772.

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