Research Article

Chemical constituents and biological activities of Artocarpus heterophyllus lam (Jackfruit): A review

Sibi G*, Pranay Raja Bhad and Meeneri Vilas Bobde

Published: 20 January, 2021 | Volume 4 - Issue 1 | Pages: 005-009

Artocarpus (Moraceae) is a deciduous tree with appreciable importance as a source of edible fruit and is widely used in folk medicines. The extracts and metabolites of Artocarpus heterophyllus particularly those from leaves, bark, stem and fruit possess several useful bioactive compounds. This review indents to compile various studies on A. heterophyllus and critically evaluates its ethnomedical and ethnopharmacological properties. Several pharmacological studies from A. heterophyllus have conclusively established their mode of action in anti-inflammatory, antimicrobial, antioxidant and anticancer activities. Based on the available data, it is concluded that Artocarpus as a promising source of useful products and opens up new avenues for novel therapeutics.

Read Full Article HTML DOI: 10.29328/journal.ijcmbt.1001019 Cite this Article Read Full Article PDF


Artocarpus heterophyllus; Jackfruit; Antimicrobial; Anticancer; Antioxidant


  1. Bhatia BS, Siddapa GS, Lal G. Composition and nutritive value of jackfruit. Indian J Agric Sci. 1955; 25: 303–306.
  2. Jagtap UB, Panaskar SN, Bapat VA. Evaluation of antioxidant capacity and phenol content in jackfruit (Artocarpus heterophyllus Lam.) fruit pulp. Plant Foods Hum Nutr. 2010; 65: 99–104. PubMed: https://pubmed.ncbi.nlm.nih.gov/20198442/
  3. Soong YY, Barlow PJ. Antioxidant activity and phenolic content of selected fruit seeds. Food Chem. 2004; 88: 411-417.
  4. Zhang L, Tu ZC, Xie X, Wang H, Wang H, et al. Jackfruit (Artocarpus heterophyllus Lam.) peel: A better source of antioxidants and α-glucosidase inhibitors than pulp, flake and seed, and phytochemical profile by HPLC-QTOF-MS/MS, Food Chem. 2017; 234: 303-313. PubMed: https://pubmed.ncbi.nlm.nih.gov/28551240/
  5. Zhang Y, Zuo H, Xu F, Zhu K, Tan L, et al. The digestion mechanism of jackfruit seed starch using improved extrusion cooking technology. Food Hydrocolloids. 2004; 110: 106154.
  6. Shafiq M, Mehmood S, Yasmin A, Khan SJ, Khan NH, et al. Evaluation of phytochemical, nutritional and antioxidant activity of indigenously grown jackfruit (Artocarpus heterophyllus Lam). J Scienti Res. 2017; 9: 135-143.
  7. Swami SB, Thakor NJ, Haldankar PM, Kalse SB. Jackfruit and its many functional components as related to human health: A Review. Comprehensive Reviews in Food Science and Food Safety. 2012; 11: 565-576.
  8. Saha RK, Jamiruddin M, Acharya S. Analysis of lectins isolated from seed and testa of Artocarpus heterophyllus LAM. International J Curr Res Chem Pharmaceut Sci. 2015; 2: 65-75.
  9. Vazquez-Gonzalez Y, Ragazzo-Sanchez JA, Calderon-Santoyo M. Characterization and antifungal activity of jackfruit (Artocarpus heterophyllus Lam.) leaf extract obtained using conventional and emerging technologies. Food Chem. 2020; 330: 127211. PubMed: https://pubmed.ncbi.nlm.nih.gov/32540527/
  10. Baliga MS, Shivashankara AR, Haniadka R, Dsouza J, Bhat HP. Phytochemistry nutritional and pharmacological properties of Artocarpus heterophyllus Lam. Food Res Int. 2011; 44: 1800-1811.


  1. Barik BR, Bhaumik T, Dey AK, Kundu AB. Triterpenoids from Artocarpus heterophyllus. Phytochemistry. 1994; 35: 1001-1004.
  2. Yuan WJ, Yuan JB, Peng JB, Ding YQ, Zhu JX, et al. Flavonoids from the roots of Artocarpus heterophyllus. Fitoterapia. 2017; 117: 133–137. PubMed: https://pubmed.ncbi.nlm.nih.gov/28163073/
  3. Arung ET, Shimizu K, Tanaka H, Kondo R. 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus. Fitoterapia. 2010; 81: 640-643.
  4. Wang XL, Shen XXT, Wang SQ, Wang XN. New phenolic compounds from the leaves of Artocarpus heterophyllus. Chin Chem Lett. 2017; 28: 37-40.
  5. Liu YP, Yu XM, Zhang W, Wang T, Jiang B, et al. Prenylated chromones and flavonoids from Artocarpus heterophyllus with their potential antiproliferative and anti-inflammatory activities. Bioorg Chem. 2020; 101: 104030. PubMed: https://pubmed.ncbi.nlm.nih.gov/32615467/
  6. Zheng ZP, Xu Y, Qin C, Zhang S, Gu X, et al. Characterization of antiproliferative activity constituents from Artocarpus heterophyllus. J Agric Food Chem. 2014; 62: 5519-5527.
  7. Zheng ZP, Cheng KW, To JK, Li H, Wang M. Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as anti-browning agent. Mol Nutr Food Res. 2008; 52: 1530-1538. PubMed: https://pubmed.ncbi.nlm.nih.gov/18683821/
  8. Zheng ZP, Chen S, Wang S, Wang XC, Cheng KW, et al. Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus. J Agric Food Chem. 2009; 57: 6649-6655. PubMed: https://pubmed.ncbi.nlm.nih.gov/19588925/
  9. Fu YH, Guo JM, Xie YT, Yu XM, QT SU, et al. Prenylated chromones from the fruits of Artocarpus heterophyllus and their potential anti-HIV-1 activities. J Agric Food Chem. 2020; 68: 2024–2030. PubMed: https://pubmed.ncbi.nlm.nih.gov/32037814/
  10. Septama AW, Jantan I, Panichayupakaranant P, Aluwi MFFM, Rahmi EP. Immunosuppressive and antibacterial activities of dihydromorin and norartocarpetin isolated from Artocarpus heterophyllus heartwoods. Asian Pacific J Trop Biomed. 2020; 10: 361-368.
  11. Fang SC, Hsu CL, Yen GC. Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem. 2008; 56: 4463-4468. PubMed: https://pubmed.ncbi.nlm.nih.gov/18500810/
  12. Liu YY, Wang T, Yang RX, Tang HX, Qiang L, et al. Anti-inflammatory steroids from the fruits of Artocarpus heterophyllus. Nat Prod Res. 2018; 22: 1–7. PubMed: https://pubmed.ncbi.nlm.nih.gov/31755785/
  13. Septama AW, Jantan I, Panichayupakaranant P. Flavonoids of Artocarpus heterophyllus Lam. heartwood inhibit the innate immune responses of human phagocytes. J Pharm Pharmacol. 2018; 70: 1242–1252. PubMed: https://pubmed.ncbi.nlm.nih.gov/29943393/
  14. Meera M, Ruckmani A, Saravanan R, Lakshmipathy Prabhu R. Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel - A comparative study. Nat Prod Res. 2018; 32: 2740–2744. PubMed: https://pubmed.ncbi.nlm.nih.gov/28990815/
  15. Yao X, Wu D, Dong N, Ouyang P, Pu J, et al. Phenolic compound isolated from Artocarpus heterophyllus, suppresses lipopolysaccharide-activated inflammatory responses in murine raw 264.7 macrophages. Int J Mol Sci. 2016; 17: 1199.
  16. Omar HS, El-Beshbishy HA, Moussa Z, Taha KF, Singab ANB. Antioxidant activity of Artocarpus heterophyllus Lam. (Jack Fruit) leaf extracts: remarkable attenuations of hyperglycemia and hyperlipidemia in streptozotocin-diabetic rats. The Scientific World J. 2011; 11: 788-800. PubMed: https://pubmed.ncbi.nlm.nih.gov/21479350/
  17. De Faria A, de Rosso V, Mercadante A. Carotenoid composition of jackfruit (Artocarpus heterophyllus), determined by HPLC-PDA-MS/MS. Plant Foods Hum Nutr. 2009; 64: 108-115. PubMed: https://pubmed.ncbi.nlm.nih.gov/19437120/
  18. Cadenas E, Packer L. (eds.), 1996, Handbook of Natural Antioxidants, Marcel Dekker Inc, New York. 1996.
  19. Jagtap UB, Waghmare SR, Lokhande VH, Suprasanna P, Bapat VA. Preparation and evaluation of antioxidant capacity of Jackfruit (Artocarpus heterophyllus Lam.) wine and its protective role against radiation induced DNA damage, Industrial Crop and Products. 2011; 34: 1595–1601.
  20. Zhu K, Yao S, Zhang Y, Liu Q, Xu F, et al. Effects of in vitro saliva, gastric and intestinal digestion on the chemical properties, antioxidant activity of polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp, Food Hydrocolloids. 2019; 87: 952-959.
  21. Zhu KX, Zhang Y, Nie SP, Xu F, He SZ, et al. Physicochemical properties and in vitro antioxidant activities of polysaccharide from Artocarpus heterophyllus Lam. pulp. Carbohyd Polym. 2017; 155: 354-361. PubMed: https://pubmed.ncbi.nlm.nih.gov/27702522/
  22. Daud MNH, Wibowo A, Abdullah N, Ahmad R. Bioassay-guided fractionation of Artocarpus heterophyllus L. J33 variety fruit waste extract and identification of its antioxidant constituents by TOFLCMS, Food Chem. 2018; 266: 200-214. PubMed: https://pubmed.ncbi.nlm.nih.gov/30381177/
  23. Daud M, Fatanah DN, Abdullah N, Ahmad R. Evaluation of antioxidant potential of Artocarpus heterophyllus L. J33 variety fruit waste from different extraction methods and identification of phenolic constituents by LCMS. Food Chem. 2017; 232: 621–632. PubMed: https://pubmed.ncbi.nlm.nih.gov/28490120/
  24. Ko FN, Cheng ZJ, Lin CN, Teng CM. Scavenger and antioxidant properties of prenylflavones isolated from Artocarpus heterophyllus. Free Radic Biol Med. 19978; 25: 160-168. PubMed: https://pubmed.ncbi.nlm.nih.gov/9667491/
  25. Zhang X, Zhu K, Xie J, Chen Y, Tan L, et al. Optimization and identification of non-extractable polyphenols in the dietary fiber of jackfruit (Artocarpus heterophyllus Lam.) pulp released by alkaline, acid and enzymatic hydrolysis: content, composition and antioxidant activities. LWT-Food Science and Technology. 2020.
  26. Biworo A, Tanjung E, Khairina I, Suhartono E. Antidiabetic and antioxidant activity of jackfruit (Artocarpus heterophyllus) extract. J Med Bioengine. 2015; 4: 318-323.
  27. Loizzo MR, Tundis R, Chandrika UG, Abeysekera AM, Menichini F, et al. Antioxidant and antibacterial activities on foodborne pathogens of Artocarpus heterophyllus Lam. (Moraceae) leaves extracts. J Food Sci. 2020; 75: M291-295. PubMed: https://pubmed.ncbi.nlm.nih.gov/20629886/
  28. Khan MR, Omoloso AD, Kihara M. Antibacterial activity of Artocarpus heterophyllus. Fitoterapia. 2003; 74: 501–505. PubMed: https://pubmed.ncbi.nlm.nih.gov/12837372/
  29. Siritapetawee J, Thammasirirak S, Samosornsuk W. Antimicrobial activity of a 48-kDa protease (AMP48) from Artocarpus heterophyllus latex. Eur Rev Med Pharmacol Sci. 2012; 16: 132–137. PubMed: https://pubmed.ncbi.nlm.nih.gov/22338560/
  30. Sibi G, Wadhavan R, Singh S, Shukla A, Dhananjaya K, et al. Plant latex: A promising antifungal agent for postharvest disease control. Pak J Biol Sci. 2013; 16: 1737-1743.
  31. Septama AW, Panichayupakaranant P. Antibacterial assay-guided isolation of active compounds from Artocarpus heterophyllus heartwoods. Pharm Biol. 2015; 53: 1608-1613. PubMed: https://pubmed.ncbi.nlm.nih.gov/25856717/
  32. Septama AW, Panichayupakaranant P. Antibacterial activity of artocarpanone isolated from Artocarpus heterophyllus heartwoods against diarrheal pathogens and its mechanism of action on membrane permeability. J Appl Pharm Sci. 2017; 7: 64-68.
  33. Ruiz-Montanez G, Burgos-Hernandez A, Calderon-Santoyo M, Lopez-Saiz CM, Velazquez-Contreras CA, et al. Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam). Food Chem. 2015; 175: 409-416. PubMed: https://pubmed.ncbi.nlm.nih.gov/25577099/
  34. Wen L, Zhao Y, Jiang Y, Yu L, Zeng X, et al. Identification of a flavonoid C-glycoside as potent antioxidant. Free Radic Biol Med. 2017; 110: 92–101. PubMed: https://pubmed.ncbi.nlm.nih.gov/28587909/
  35. Arung ET, Wicaksono BD, Handoko YA, Kusuma IW, Shimizu K, et al. Cytotoxic effect of artocarpin on T47D cells. J Nat Med. 2010; 64: 423-429. PubMed: https://pubmed.ncbi.nlm.nih.gov/20544395/
  36. Burci LM, da Silva CB, Rondon JN, da Silva LM, de Andrade SF, et al. Acute and subacute (28 days) toxicity, hemolytic and cytotoxic effect of Artocarpus heterophyllus seed extracts. Toxicol Rep. 2018; 6: 1304-1308. PubMed: https://pubmed.ncbi.nlm.nih.gov/31993330/
  37. Sun G, Zheng Z, Lee MH, Xu Y, Kang S, Dong Z, et al. Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus. J Agric Food Chem. 2017; 65: 3474-3480. PubMed: https://pubmed.ncbi.nlm.nih.gov/28391699/
  38. Wiater A, Paduch R, Trojnar S, Choma A, Pleszczynska M, et al. The effect of water-soluble polysaccharide from jackfruit (Artocarpus heterophyllus Lam.) on human colon carcinoma cells cultured in vitro. Plants (Basel). 2020; 9: 103. PubMed: https://pubmed.ncbi.nlm.nih.gov/31947694/
  39. Boonyaketgoson S, Rukachaisirikul V, Phongpaichit S, Trisuwan K. Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus. Tetrahed Lett. 2017; 58: 1585-1589.
  40. Nguyen NT, Nguyen MHK, Nguyen HX, Bui NKN, Nguyen MTT. Tyrosinase inhibitors from the wood of Artocarpus heterophyllus. J Nat Prod. 2012; 75: 1951-1955. PubMed: https://pubmed.ncbi.nlm.nih.gov/23113717/
  41. Johnston CS, Steplewsk I, Long CA, Harris LN, Ryals RH, Examination of the antiglycemic properties of vinegar in healthy adults. Ann Nutr Metab. 2010; 56: 74-79. PubMed: https://pubmed.ncbi.nlm.nih.gov/20068289/
  42. Kazeem MI, Raimi OG, Balogun RM, Ogundajo AL. Comparative study on the α-amylase and α-glucosidase inhibitory potential of different extracts of Blighia sapida Koenig. Am J Res Commun. 2013; 1: 178-192. www.usajournals.com
  43. Ajiboye BO, Ojo OA, Adeyonu O, Imiere O, Olayide I, et al. Inhibitory effect on key enzymes relevant to acute type-2 diabetes and antioxidative activity of ethanolic extract of Artocarpus heterophyllus stem bark. J Acute Dis. 5: 423-429.

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